FULL liver panel (ANA, AMA, ASMA, anti-LKM)
Material: Blood
Test price: PLN 160.00
Waiting time for results: result after 7 working days
Reservation:
Test price: PLN 160.00
Waiting time for results: result after 7 working days
Reservation:
- Check the opening hours of the collection point and where an appointment is required.
Preparation for the examination
General
- The material for testing is blood.
- The patient does not need to fast. It is recommended to drink a glass of water approximately 30 minutes before the examination.
Description
A liver function panel (ANA, AMA, ASMA, LKM) allows for a comprehensive diagnosis of autoimmune liver diseases.
Antibodies against liver and kidney microsomes (LKM) are present in various forms of chronic hepatitis.
Antibodies directed against LKM-1 are considered a marker of autoimmune hepatitis II. Children constitute 50 to 75% of all affected patients. Extrahepatic manifestations, such as arthralgia, glomerulonephritis, vitiligo, and chronic inflammatory liver diseases, are often associated with autoimmune hepatitis.
There are nine types of antimitochondrial antibodies (AMA), which can indicate various diseases. M2 antibodies are a sensitive and specific diagnostic marker for primary biliary cirrhosis. These antibodies can also be present—usually at low titers—in other chronic liver diseases (30% of cases) as well as in progressive systemic sclerosis. In patients with progressive scleroderma who are positive for M2 antibodies, a clinical overlap syndrome with primary biliary cirrhosis may occur. Anti-smooth muscle antibodies (ASMA) may be present in serum in various liver diseases (chronic hepatitis, cirrhosis). Detection of these antibodies is particularly important in the diagnosis of autoimmune chronic active hepatitis (CAH). They can also be detected in infectious mononucleosis and other viral diseases, as well as in lupus erythematosus, breast cancer, ovarian cancer, and malignant melanoma, but they do not play a significant diagnostic role. After viral hepatitis, antibody titers usually decline rapidly.
High concentrations of anti-smooth muscle antibodies indicate chronic active hepatitis, with a prevalence of 70%.
IgG and IgM antibody titers may correlate with disease activity. CAH occurs primarily in women, with half of cases developing before the age of 30.
Low titers of anti-smooth muscle antibodies are found in patients with primary biliary cirrhosis (50%), alcoholic cirrhosis, biliary obstruction and in approximately 2% of asymptomatic individuals.
Antibodies against liver and kidney microsomes (LKM) are present in various forms of chronic hepatitis.
Antibodies directed against LKM-1 are considered a marker of autoimmune hepatitis II. Children constitute 50 to 75% of all affected patients. Extrahepatic manifestations, such as arthralgia, glomerulonephritis, vitiligo, and chronic inflammatory liver diseases, are often associated with autoimmune hepatitis.
There are nine types of antimitochondrial antibodies (AMA), which can indicate various diseases. M2 antibodies are a sensitive and specific diagnostic marker for primary biliary cirrhosis. These antibodies can also be present—usually at low titers—in other chronic liver diseases (30% of cases) as well as in progressive systemic sclerosis. In patients with progressive scleroderma who are positive for M2 antibodies, a clinical overlap syndrome with primary biliary cirrhosis may occur. Anti-smooth muscle antibodies (ASMA) may be present in serum in various liver diseases (chronic hepatitis, cirrhosis). Detection of these antibodies is particularly important in the diagnosis of autoimmune chronic active hepatitis (CAH). They can also be detected in infectious mononucleosis and other viral diseases, as well as in lupus erythematosus, breast cancer, ovarian cancer, and malignant melanoma, but they do not play a significant diagnostic role. After viral hepatitis, antibody titers usually decline rapidly.
High concentrations of anti-smooth muscle antibodies indicate chronic active hepatitis, with a prevalence of 70%.
IgG and IgM antibody titers may correlate with disease activity. CAH occurs primarily in women, with half of cases developing before the age of 30.
Low titers of anti-smooth muscle antibodies are found in patients with primary biliary cirrhosis (50%), alcoholic cirrhosis, biliary obstruction and in approximately 2% of asymptomatic individuals.
Preparation and development of material (applies only to contractors)
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