FULL liver panel (ANA,AMA,ASMA,anti-LKM)
Material: Blood
Study price: PLN 135.00
Waiting time: result after 7 working days
Booking:
Study price: PLN 135.00
Waiting time: result after 7 working days
Booking:
- Check, the hours of operation of the collection center and where booking an appointment is required.
Preparation for the study
General
- The test material is blood.
- The patient does not need to be fasting.About 30 minutes before the test it is advisable to drink a glass of water.
Description
The liver panel (ANA, AMA, ASMA, LKM) allows a complete diagnosis of autoimmune liver diseases.
Antibodies against kidney and liver microsomes (LKM- liver kidney microsomes) are found in various forms of chronic hepatitis.
Antibodies directed against LKM-1 are recognized as a marker of autoimmune hepatitis type II. Children account for 50 to 75% of all affected patients. Extrahepatic manifestations, i.e., arthralgias, glomerulonephritis, vitiligo and chronic inflammatory liver disease, are often associated with autoimmune hepatitis.
There are nine types of anti-mitochondrial antibodies (AMA), which can indicate various diseases. M2 antibodies are a sensitive and specific diagnostic marker for primary biliary cirrhosis. These antibodies can besides - mostly at low titers - be found in the course of other chronic liver diseases (30% of cases), as well as in progressive generalized scleroderma. Patients with progressive scleroderma who have M2 antibodies may have a clinical overlap syndrome with primary biliary cirrhosis. Anti-smooth muscle antibodies (ASMA) may be present in serum in the course of various liver diseases (chronic hepatitis, cirrhosis). It is particularly important to determine these antibodies in the diagnosis of autoimmune chronic active hepatitis (CAH). They can also be detected in the course of infectious mononucleosis and other viral diseases, as well as visceral lupus, breast cancer, ovarian cancer, malignant melanoma, however, they do not play an important diagnostic role. After hepatitis (viral hepatitis), antibody titers usually fall quickly.
High concentrations of anti-smooth muscle antibodies indicate chronic active hepatitis, the prevalence of antibodies is 70%.
IgG and IgM class antibody titers can correlate with disease activity. CAH occurs primarily in women, half of the cases develop before the age of 30.
Low titers of anti-smooth muscle antibodies are found in patients with primary biliary cirrhosis (50%), post-alcoholic cirrhosis, biliary obstruction and in about 2% of asymptomatic individuals.
Antibodies against kidney and liver microsomes (LKM- liver kidney microsomes) are found in various forms of chronic hepatitis.
Antibodies directed against LKM-1 are recognized as a marker of autoimmune hepatitis type II. Children account for 50 to 75% of all affected patients. Extrahepatic manifestations, i.e., arthralgias, glomerulonephritis, vitiligo and chronic inflammatory liver disease, are often associated with autoimmune hepatitis.
There are nine types of anti-mitochondrial antibodies (AMA), which can indicate various diseases. M2 antibodies are a sensitive and specific diagnostic marker for primary biliary cirrhosis. These antibodies can besides - mostly at low titers - be found in the course of other chronic liver diseases (30% of cases), as well as in progressive generalized scleroderma. Patients with progressive scleroderma who have M2 antibodies may have a clinical overlap syndrome with primary biliary cirrhosis. Anti-smooth muscle antibodies (ASMA) may be present in serum in the course of various liver diseases (chronic hepatitis, cirrhosis). It is particularly important to determine these antibodies in the diagnosis of autoimmune chronic active hepatitis (CAH). They can also be detected in the course of infectious mononucleosis and other viral diseases, as well as visceral lupus, breast cancer, ovarian cancer, malignant melanoma, however, they do not play an important diagnostic role. After hepatitis (viral hepatitis), antibody titers usually fall quickly.
High concentrations of anti-smooth muscle antibodies indicate chronic active hepatitis, the prevalence of antibodies is 70%.
IgG and IgM class antibody titers can correlate with disease activity. CAH occurs primarily in women, half of the cases develop before the age of 30.
Low titers of anti-smooth muscle antibodies are found in patients with primary biliary cirrhosis (50%), post-alcoholic cirrhosis, biliary obstruction and in about 2% of asymptomatic individuals.
Development and preparation of material (applies to contractors only)
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