Anti-sn RNP- IgG antibodies (ELISA)
Material: Blood
Test price: PLN 50
Waiting time for results: result after 5 working days
Reservation:
Test price: PLN 50
Waiting time for results: result after 5 working days
Reservation:
- Check the opening hours of the collection point and where an appointment is required.
Preparation for the examination
General
- The material for testing is blood.
- The patient does not need to fast. It is recommended to drink a glass of water approximately 30 minutes before the examination.
Description
The U1-snRNP complex is a nuclear ribonucleoprotein particle composed of uridine-rich RNA, a set of proteins known as the 70-kDa U1-RNP, and an Sm (Smith antigen) molecule.
Antibodies to the snRNP complex belong to a heterogeneous group of antinuclear antibodies associated with autoimmune diseases. Antibodies to the snRNP complex react specifically with both the Sm antigen and a set of proteins known as the 70-kDa U1-RNP. They are typically present in patients with systemic lupus erythematosus (SLE) and mixed connective tissue disease (MCTD), but also occur in Sjögren's syndrome, scleroderma, and polymyositis.
Differentiation of autoantibodies by ELISA using a specific antigen is helpful in differentiating SLE from MCTD. Antibodies against the U1-RNP 70kDa protein complex are present in approximately 95% of patients with MCTD and in 40% of patients with SLE (the detected presence of anti-U1 RNP antibodies is a typical symptom of Sharp's syndrome). Antibodies against Sm are highly specific for SLE.
Antibodies to the snRNP complex belong to a heterogeneous group of antinuclear antibodies associated with autoimmune diseases. Antibodies to the snRNP complex react specifically with both the Sm antigen and a set of proteins known as the 70-kDa U1-RNP. They are typically present in patients with systemic lupus erythematosus (SLE) and mixed connective tissue disease (MCTD), but also occur in Sjögren's syndrome, scleroderma, and polymyositis.
Differentiation of autoantibodies by ELISA using a specific antigen is helpful in differentiating SLE from MCTD. Antibodies against the U1-RNP 70kDa protein complex are present in approximately 95% of patients with MCTD and in 40% of patients with SLE (the detected presence of anti-U1 RNP antibodies is a typical symptom of Sharp's syndrome). Antibodies against Sm are highly specific for SLE.
Preparation and development of material (applies only to contractors)
1046
Anti-RNP/Sm antibodies, lupus, mixed connective tissue disease, U1-sn RNP
