Coagulation factor IX
Material: Blood
Test price: PLN 154
Waiting time for results: result after 10 working days
Reservation:
Test price: PLN 154
Waiting time for results: result after 10 working days
Reservation:
- We only perform testing at selected collection points/hours – PLEASE NOTE! Check testing hours and where appointments are required.
Preparation for the examination
General
- The material for testing is blood.
- The patient must not be undergoing treatment with high molecular weight heparin.
- The patient does not need to fast.
Important
Samples brought from outside are not accepted for testing.
Description
Coagulation factor IX (FIX, Christmas factor, antihemophilic factor B)
FIX is a vitamin K-dependent glycoprotein. It is activated by VIIa/TF or XIa. Once activated, factor IXa activates factor X in the presence of factor VIIIa, platelet phospholipids, and calcium ions. FVIIIa is an essential cofactor for factor IXa. Therefore, deficiency of either factor has a similar clinical picture. FIX deficiency is associated with hemophilia B. Laboratory tests in most cases of hemophilia B show a prolonged APTT with a normal INR. Factor IX measurement is necessary to establish the diagnosis.
Reduced FIX activity occurs in:
• Congenital factor IX deficiency (hemophilia B)
• Treatment with vitamin K antagonists
• Significant liver damage
• Amyloidosis
• Treatment with valproic acid
• Vitamin K deficiency
• Acquired FIX deficiency (rarely in cancer and autoimmune diseases, after surgery)
FIX is a vitamin K-dependent glycoprotein. It is activated by VIIa/TF or XIa. Once activated, factor IXa activates factor X in the presence of factor VIIIa, platelet phospholipids, and calcium ions. FVIIIa is an essential cofactor for factor IXa. Therefore, deficiency of either factor has a similar clinical picture. FIX deficiency is associated with hemophilia B. Laboratory tests in most cases of hemophilia B show a prolonged APTT with a normal INR. Factor IX measurement is necessary to establish the diagnosis.
Reduced FIX activity occurs in:
• Congenital factor IX deficiency (hemophilia B)
• Treatment with vitamin K antagonists
• Significant liver damage
• Amyloidosis
• Treatment with valproic acid
• Vitamin K deficiency
• Acquired FIX deficiency (rarely in cancer and autoimmune diseases, after surgery)
Zwiększona aktywność FIX występuje w:
• Cukrzycy
• Kortykosteroidoterapii
Zwiększona aktywność FIX wiąże się ze zwiększonym ryzykiem wystąpienia incydentów sercowo- naczyniowych. Zaleca się oznaczenia tego białka w diagnostyce zakrzepicy zylnej o nieznanej przyczynie.
Preparation and development of material (applies only to contractors)
284
Coagulation factor IX (FIX, Christmas factor, antihemophilic factor B)
