Coagulation factor VII

• The material for testing is blood.
• The patient must not be undergoing treatment with high molecular weight heparin.
• The patient does not need to fast.

Samples brought from outside are not accepted for testing.

Factor VII (proconvertin, F VII) is a vitamin K-dependent blood coagulation factor in the extrinsic system, synthesized in the liver. It is secreted into the blood in an inactive form. Its conversion occurs under the influence of active coagulation factors and also through autocatalysis by FVIIa, the concentration of which is very low. Circulating F VIIa combines with tissue factor TF (Tissue Factor) to form the TF-F VIIa complex, which rapidly accelerates further FVII activation and thrombin generation. Activation of factor VII to VIIa is also catalyzed by other proteases: thrombin and factor X, as well as factors IXa, Xa, XIa, and XIIa. Active factor VIIa in complex with TF activates factors X and IX, leading to the coagulation reaction. The physiological inhibitor of this process is TFPI (Tissue Factor Pathway Inhibitor).
Coagulation factor VII is determined in the case of its deficiency or increased activity, in the case of abnormal PT and aPTT results, and in the presence of abnormal bleeding or thrombotic events.

Factor VII deficiency is a rare condition associated with quantitative (concentration) or qualitative (activity) changes that lead to bleeding. Factor VII activity of less than 1% can cause life-threatening bleeding, including joint and central nervous system hemorrhages. Factor VII deficiency may be associated with the use of oral anticoagulants, cephalosporins, or penicillin.

Increased levels of factor VII, caused by mutations, increased TF expression, hypertension, and diabetes—especially when complicated by microalbuminuria—lead to the development of thrombotic diseases.
Factor VII, alongside platelets, is one of the main drivers of thrombin and fibrin generation in atherosclerotic plaques, leading to thrombus growth and the development of atherosclerosis and acute vascular events. Therefore, it is a risk factor for atherosclerosis and the progression of coronary heart disease.

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