Coagulation factor XI
Material: Blood
Test price: PLN 154
Waiting time for results: result after 10 working days
Reservation:
Test price: PLN 154
Waiting time for results: result after 10 working days
Reservation:
- We only perform testing at selected collection points/hours – PLEASE NOTE! Check testing hours and where appointments are required.
Preparation for the examination
General
- The material for testing is blood.
- The patient must not be undergoing treatment with high molecular weight heparin.
- The patient does not need to fast.
Important
Samples brought from outside are not accepted for testing.
Description
Factor XI is a protein composed of two chains linked by a disulfide bond. Only its dimeric form can be secreted from cells. The factor is produced in the liver in an inactive form (proenzyme). Its activation occurs primarily in the presence of active factor XII (XIIa), the enzyme thrombin. Factor XI circulates in the blood in complexes with high-molecular-weight kininogen.
Factor XIa inhibitors include antithrombin, alpha-1 antitrypsin, C1 inhibitor, and alpha-2 antiplasmin. Congenital factor XI deficiency (hemophilia C) is rare. Factor XI deficiency results in bleeding following dental procedures, surgery, or trauma. In women, it may manifest as heavy bleeding during menstruation.
The test is performed in the event of discrepancies in the results of basic coagulation tests: abnormal APTT and normal PT, and in the event of abnormal bleeding in the clinical history of the examined person.
Preparation and development of material (applies only to contractors)
290
