Coagulation factor XI

Material: Blood
Price of the study: 154 PLN
Waiting time: result after 10 working days
Booking:

We perform the test without prior reservation only at selected intake points/hours - NOTE! Check the hours of the tests

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Preparation for the study

General

The test material is blood.
The patient must not be on high-molecular-weight heparin treatment.
The patient does not need to be fasting.

Important

Samples brought from outside are not accepted for testing.

Description

Factor XI is a protein composed of two chains linked by a sulfide bridge. Only its dimeric form can be secreted from the cell. The factor is produced in the liver in an inactive form (proenzyme). Its activation occurs mainly in the presence of active factor XII (XIIa), an enzyme - thrombin. Factor XI circulates in the blood in complexes with high-molecular-weight kininogen.

Inhibitors of factor XIa are antithrombin , alpha-1 antitrypsin, C1 inhibitor, alpha-2 antiplasmin. Congenital factor XI deficiency (hemophilia C) is rare. Factor XI deficiency results in bleeding, due to dental or surgical procedures or trauma. In women, it can manifest as heavy bleeding during menstrual periods.

The test is performed in case of inconsistent results of basic coagulation tests: abnormal APTT and normal PT, and in case of abnormal bleeding in the subject's clinical history.