Coagulation factor XII
Material: Blood
Test price: PLN 170
Waiting time for results: result after 10 working days
Reservation:
Test price: PLN 170
Waiting time for results: result after 10 working days
Reservation:
- We only perform testing at selected collection points/hours – PLEASE NOTE! Check testing hours and where appointments are required.
Preparation for the examination
General
- The material for testing is blood.
- The patient must not be undergoing treatment with high molecular weight heparin.
- The patient does not need to fast.
Important
Samples brought from outside are not accepted for testing.
Description
Factor XII (FXII, Hageman factor) is a glycoprotein produced in the liver in an inactive form. The enzymes that activate FXII are kallikrein, FXIa, plasmin, and trypsin. The main inhibitor of FXII is C1 esterase inhibitor.
It is a so-called contact factor, which, as part of the coagulation system, participates in the formation of bonds with phospholipids.
Causes of decreased FXII activity include:
• Thrombosis
• Nephrotic syndrome
• States of increased fibrinolysis
• Congenital FXII deficiency
Causes of increased FXII activity include:
• Diabetes
Reduced FXII activity is usually detected incidentally in people with significantly prolonged aPTT and is not associated with an increased risk of bleeding or thrombosis. In such cases, aPTT cannot be used to monitor unfractionated heparin treatment; anti-Xa activity should be measured.
It is a so-called contact factor, which, as part of the coagulation system, participates in the formation of bonds with phospholipids.
Causes of decreased FXII activity include:
• Thrombosis
• Nephrotic syndrome
• States of increased fibrinolysis
• Congenital FXII deficiency
Causes of increased FXII activity include:
• Diabetes
Reduced FXII activity is usually detected incidentally in people with significantly prolonged aPTT and is not associated with an increased risk of bleeding or thrombosis. In such cases, aPTT cannot be used to monitor unfractionated heparin treatment; anti-Xa activity should be measured.
Preparation and development of material (applies only to contractors)
285
Factor XII (FXII, Hageman factor)
