Von Willebrand factor activity

• The material for testing is blood.
• The patient must not be undergoing treatment with high molecular weight heparin.
• The patient does not need to fast.

Samples brought from outside are not accepted for testing.

Von Willebrand factor is a plasma glycoprotein composed of multimers composed of subunits of approximately 250 kDa. High-molecular-weight vWF multimers support platelet adhesion at the site of blood vessel damage by binding to collagen and platelets. VWF binds to and stabilizes factor VIII, thus defects in VWF cause bleeding similar to that associated with platelet dysfunction or observed in hemophilia. VWF is a congenital coagulation disorder associated with a quantitative or qualitative deficiency of von Willebrand factor.
Acquired von Willebrand syndrome is associated with VWF deficiency and reduced activity, which is sometimes observed in lymphatic or myeloproliferative diseases, cancers, and autoimmune diseases.
Many patients with mild disease may be asymptomatic. The most common symptoms include:
– excessive menstrual bleeding
– easy bruising
– nose and gum bleeding
– prolonged bleeding from small wounds
– bleeding after tooth extraction
– bleeding after injuries or surgery
– intra-articular and intramuscular hemorrhages similar to those in hemophilia.

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