EBV test Euroline (EUROIMMUN) IgM

• The material for testing is blood.
• The patient does not need to fast.

Epstein-Barr virus (EBV) is one of the most common human herpes viruses. It causes infectious mononucleosis, an illness characterized by fever, sore throat, enlarged lymph nodes, and often an enlarged liver and/or spleen.

The immune response to EBV infection is characterized by the production of antibodies against the capsid antigen VCA, nuclear antigens (EBNA) and early antigens (EA).

The Euroline EBV test is used for the qualitative detection of human antibodies against 5 different EBV antigens: VCA gp 125, VCA p19, EBNA-1, p22, and EA-D in serum for the diagnosis of Epstein-Barr virus infections (infectious mononucleosis, Burkitt's lymphoma, nasopharyngeal carcinoma). It is based on recombinant and native, highly purified antigens and enables the differentiation between acute and past infection in a single reaction.

Markers of the late phase of infection are IgG antibodies directed against VCA gp 125 and/or p19, as well as EBNA-1 antibodies. Anti-p22- also indicate the late phase and appear in the case of secondary loss of anti-EBNA-1 antibodies.

The presence of IgG and IgM antibodies against VCA gp 125 and/or p19 antigens is characteristic of primary infection. EA-D antibodies may also be present in the early phase of infection.

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