Endometriosis-EndoRNA-genetic test

Samples brought from outside are not accepted for testing.

EndoRNA testing is useful in diagnosing patients with suspected endometriosis.
The test result allows you to rule out or confirm the disease.
Endometriosis is a disease characterized by the presence of tissues similar to endometrial structures outside the uterine cavity. These structures are secretory and respond to hormonal changes occurring during the menstrual cycle, triggering a chronic inflammatory response in the body.
The disease manifests itself as recurrent pain occurring around the menstrual period. It can also include constant pain, pain in the lower back, and pain during intercourse, urination, or defecation. The pain is often severe and interferes with daily activities. According to WHO data, as many as 3 million women in Poland may suffer from this condition.
Due to the many, often atypical, symptoms of the disease, endometriosis is difficult to diagnose and, if left untreated, may lead to infertility.

EndoRNA is a genetic test performed using qRT-PCR. The test detects the expression of the gene encoding the enzyme fucosyltransferase 4 (FUT4). This enzyme is involved in the process of
protein fucosylation, particularly in the biosynthesis of 1,3-fucosylated glycans. Studies have shown that protein glycosylation is associated with numerous pathological and physiological processes. Elevated levels of FUT4 gene expression may indicate endometriosis.
The test is minimally invasive for patients and involves sampling the endometrium by
aspiration biopsy during the secretory phase of the menstrual cycle.

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