Fecal calprotectin (quantitative)

• For testing, a hazelnut-sized stool sample should be collected in a disposable container (without transport medium or preservatives).
• Until the stool is delivered to the collection point, the sealed container with the collected material should be stored in a cool place, but not longer than 2 days.
• The container containing the collected material must be signed.
• It is recommended to collect the first excreted portion of stool for testing along with the accompanying secretions
  (if present).

Calprotectin is a calcium-binding protein that constitutes 60% of the cytosolic protein of neutrophils, with bacteriostatic and fungicidal properties. It is a useful biomarker for assessing the activity of inflammatory bowel disease. Inflammatory bowel disease, which includes Crohn's disease and ulcerative colitis, is associated with increased neutrophilia. Fecal calprotectin testing is also useful for differentiating organic from functional gastrointestinal diseases (irritable bowel syndrome). This test is particularly recommended in children whose colonoscopy requires general anesthesia.

Detection of calprotectin in stool may also indicate disease recurrence.

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