Creatinine clearance

• The test material consists of blood collected for clotting and urine from a 24-hour urine collection.
  Blood should be collected on the day the urine collection is completed.
  Creatinine clearance must be determined by providing information on the volume of urine collected
  during the 24-hour period (provided by the patient).
  The 24-hour urine collection procedure:
  1. Prepare a clean container with a capacity of 2-3 liters.
  2. Begin urine collection in the morning of the day before the test. Use morning urine and urinate after the night.
  3. From then on, collect each urine sample in the prepared container, including the morning urine sample the following day.
  4. Mix the collected urine thoroughly. Measure the volume of the collected urine, pour approximately 100-200 ml of urine from a large container into a urinalysis container, and deliver the prepared sample to the laboratory.
  5. Label the sample container with the following information: first name, last name, total urine volume, and collection start and end time.
  The container with the urine collected during the 24-hour collection should be stored in a cool and dark place.
• The patient does not need to fast. It is recommended to drink a glass of water approximately 30 minutes before the examination.

Endogenous creatinine clearance measures the kidneys' ability to clear the blood of a given substance (creatinine). Creatinine is filtered in the renal glomeruli without undergoing secretion or reabsorption in the renal tubules.

It is a measure of glomerular filtration rate and a useful parameter in diagnosing and monitoring renal failure. Clearance is independent of diet and depends on age and gender. A decrease in creatinine clearance is the earliest sign of renal excretory failure.

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