Creatinine clearance

• The test material is blood collected for clotting and urine from daily urine collection.
  Blood should be collected on the day the urine collection is completed.
  To determine creatinine clearance, it is necessary to provide information on the volume of urine collected
  during the day (provided by the patient).
  How to carry out a daily urine collection:
  1. prepare a clean vessel with a volume of 2-3 liters.
  2. urine collection begins in the morning of the day before the test. Morning urine, after the night, return to the toilet.
  3.From then on, collect each portion of urine into the prepared vessel, including the morning portion of the next day's urine.
  4. mix the collected urine thoroughly. Measure the volume of collected urine, pour about 100- 200 ml of urine from the large vessel into the container for urinalysis, and deliver the sample so prepared to the laboratory.
  (5) Describe the container with the sample: name, surname, the volume of the entire urine collection, the time of beginning and ending of the collection.
  Store the container with the urine collected during the daily collection in a cool and dark place.
• The patient does not need to be fasting.About 30 minutes before the test, it is advisable to drink a glass of water or bitter(unsweetened) tea.

Endogenous creatinine clearance refers to the ability of the kidneys to clear the blood of a substance (creatinine). Creatinine is filtered in the renal glomeruli without undergoing secretion and reabsorption in the renal tubules.

It is a measure of glomerular filtration rate and a convenient parameter in the diagnosis and monitoring of renal failure. The clearance value is not related to diet and depends on age and gender. A decrease in creatinine clearance is the earliest signal of renal excretory failure.

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