Smallpox IgM for pregnant women

• The test material is blood.
• The patient does not need to be fasting.

The test performed for pregnant women is in CITO mode due to the fact that the treatment for seronegative pregnant women who have been in contact with a person with chickenpox is the administration of VZIG ( varicella zoster immune globulin) immunoglobulin up to 72-96 hours after exposure.

Depending on the duration of pregnancy, infection with the smallpox virus can have serious consequences for the fetus.

It can cause miscarriage or preterm labor.

The risk of birth defects is 0.4 percent to 2.0 percent if the infection occurs between 13 and 20 weeks of pregnancy. The syndrome of birth defects in fetuses infected with the smallpox virus includes scarring lesions on the skin, underdevelopment of the lower extremities, hypoplasia of the fingers, defects of the central nervous system and visual organs, and delay in psychomotor development. In the course of smallpox virus infection, generalized fetal edema, dilatation of the ventricles of the brain and delayed intrauterine growth of the fetus are also observed.

Chickenpox virus infection after 20 weeks of pregnancy is associated with a risk of about 2 percent of developing hemiplegia during the first two years of life. Infection during the perinatal period results in the onset of chickenpox symptoms in the newborn in 30 percent of cases. Newborns with congenital smallpox virus infection are more likely to develop pneumonia, chorioretinitis and seizures. The risk to the fetus is posed only by primary infection, as there is no evidence of postnatal transmission of the virus during reactivation of latent infection. Therefore, hemiplegia in a pregnant woman does not pose a risk to the fetus because it is not accompanied by generalized viremia.

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