Mitochondrial p/cp (AMA) met. IIF

• The material for testing is blood.
• The patient does not need to fast. It is recommended to drink a glass of water approximately 30 minutes before the examination.

Indirect immunofluorescence (IIF) is used to assess antimitochondrial antibodies (AMA) (frozen rat kidney sections are the standard substrate). If the test result indicates reactivity at a titer of 1:100 or higher, monospecific tests (e.g., ELISA, Western blot) should be performed to determine the specific mitochondrial antigens targeted by the antibodies.

There are nine types of antimitochondrial antibodies, which can indicate various diseases. For example, M1 occurs primarily in syphilis (100%), as well as in systemic lupus erythematosus and other autoimmune diseases, recurrent abortions, and thrombosis. M2, M4, M8, and M9 antibodies occur primarily in primary biliary cirrhosis, and M3 in pseudolupus syndrome induced by drugs such as pyrazolone. M7 antibodies occur in acute myocarditis.

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