Antibodies to bile ducts

• The test material is blood.
• The patient does not need to be fasting.About 30 minutes before the test, it is advisable to drink a glass of water or bitter(unsweetened) tea.

Determination of autoantibodies against bile ducts, by indirect immunofluorescence (IIF), is the second most specific test used in the diagnosis of primary biliary cirrhosis. Primary biliary cirrhosis, or PBC, is manifested by damage to the internal bile ducts, which leads to cholestasis. This is followed by inflammation, fibrosis and cirrhosis. Anti-mitochondrial autoantibodies, AMA (anti-mitochondrial antibodies), are involved in the pathomechanism. Determination of AMA type 2 antibodies shows the highest specificity for PBC reaching up to 95% of cases, the determination of anti-mitochondrial antibodies, with a specificity of 75%, is the second most specific test in the diagnosis of PBC.

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