Anti-prothrombin IgM antibodies
Material: Blood
Test price: PLN 71.00
Waiting time for results: result after 25 working days
Reservation:
Test price: PLN 71.00
Waiting time for results: result after 25 working days
Reservation:
- Check the opening hours of the collection point and where an appointment is required.
Preparation for the examination
General
- The material for testing is blood.
- The patient does not need to fast. It is recommended to drink a glass of water approximately 30 minutes before the examination.
Description
antibodies are a strong marker of APS.
Antiphospholipid syndrome (APS), also known as Hughes syndrome, is characterized by symptoms of vascular thrombosis and recurrent miscarriages, along with the presence of serum antibodies specific for anionic phospholipids and phospholipid-binding proteins. Clinical criteria for antiphospholipid syndrome include:
1. vascular thrombosis;
2. spontaneous miscarriages.
The following hypotheses regarding the pathogenetic role of aPT are proposed:
aPTs inhibit the modulating effect of thrombin on endothelial cells, which may impair prostacyclin release and inhibit the activation of protein C; aPTs recognize the PT/phospholipid anion complex on the surface of endothelial cells, which induces prothrombotic reactions with the participation of prothrombin; aPTs may increase the affinity of prothrombin for phospholipids and thus induce thrombotic mechanisms.
Antiphospholipid syndrome (APS), also known as Hughes syndrome, is characterized by symptoms of vascular thrombosis and recurrent miscarriages, along with the presence of serum antibodies specific for anionic phospholipids and phospholipid-binding proteins. Clinical criteria for antiphospholipid syndrome include:
1. vascular thrombosis;
2. spontaneous miscarriages.
The following hypotheses regarding the pathogenetic role of aPT are proposed:
aPTs inhibit the modulating effect of thrombin on endothelial cells, which may impair prostacyclin release and inhibit the activation of protein C; aPTs recognize the PT/phospholipid anion complex on the surface of endothelial cells, which induces prothrombotic reactions with the participation of prothrombin; aPTs may increase the affinity of prothrombin for phospholipids and thus induce thrombotic mechanisms.
Preparation and development of material (applies only to contractors)
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Anti-prothrombin IgM antibodies
