Marking the G1691A mutation in the factor V gene (mutation Leiden)

• The test is collected at a dedicated Collection Point.
• The patient does not need to fast. It is recommended to drink a glass of water approximately 30 minutes before the examination.

Samples brought from outside are not accepted for testing.

"Determination of the G1691A mutation in the Factor V gene (Leiden mutation).
The test detects the presence of the Factor V Leiden mutation. The Factor V Leiden G1691A mutation is a guanine nucleotide substitution for adenine at position 1691, which causes factor V resistance to proteolysis by protein C. This mutation causes an increased risk of thrombophilia (venous and arterial thrombosis, heart attack, stroke), recurrent miscarriages and is the main congenital cause of an increased risk of thromboembolism. The frequency of the mutation ranges from 5% to 16% in the general population. This mutation is inherited in an autosomal dominant manner. A person who is heterozygous for the Leiden mutation has a 5-7 times higher risk of thrombosis than a person without the mutation. Hormonal contraception, cancer, and surgical procedures increase the risk of thrombosis even further. 30-fold increased risk of thrombosis. A person homozygous for the Leiden mutation has an 80-fold increased risk of developing

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